| Safari (Apple) | 2.2 |
| SampleTank (IK Multimedia) | 2.7 |
| Scelight (Andras Belicza) | 2.1 |
| Schism Tracker | 4.0 |
| Scratch (MIT) | 3.9 |
| Scribus | 3.1 |
| ScummVM | 2.3 |
| SeaMonkey (Mozilla) | 3.4 |
| Sheets (Google) | 2.9 |
| SimCity 4 (Electronic Arts) | 3.9 |
| Simple MP4 Video Player (BIT LABS) | 3.5 |
| SketchUp (Trimble) | 3.3 |
| Skype (Microsoft) | 2.7 |
| Slides (Google) | 3.5 |
| Smart Converter (ShedWorx) | 2.9 |
| SmartMusic (MakeMusic) | 3.8 |
| Snagit (TechSmith) | 3.5 |
| Snap (Jens Monig) | 3.8 |
| SnapGene (GSL Biotech) | 2.0 |
| Snes9x | 3.6 |
| SolidWorks (Dassault Systemes) | 3.2 |
| SolidWorks eDrawings Viewer (Dassault Systemes) | 2.7 |
| SONAR (Cakewalk) | 3.1 |
| Songtrix (ChordWizard) | 1.7 |
| Sound Forge Pro (MAGIX) | 2.1 |
| SoX | 2.7 |
| Spark Studio (WOW Innovation Technology) | 1.9 |
| Spatterlight | 3.7 |
| SpectraLayers Pro (Steinberg) | 2.2 |
| SpeedGrade (Adobe) | 2.2 |
| SPSS (IBM) | 3.7 |
| SQL Server (Microsoft) | 4.0 |
| SQLite | 3.6 |
| Star Wars Jedi Knight Jedi Academy (Raven Software) | 3.8 |
| StarCraft (Blizzard) | 2.9 |
| StarCraft 2 (Blizzard) | 3.8 |
| Steam (Valve) | 3.9 |
| StepMania | 3.7 |
| StormLib Library (Ladislav Zezula) | 3.0 |
| StuffIt Deluxe (Smith Micro) | 3.4 |
| Stuffit Deluxe Mac (Smith Micro) | 3.1 |
| Stylus Studio (Progress) | 4.0 |
| Sublime Text (Sublime HQ) | 2.4 |
| SuperTux | 2.5 |
| Surfer (Golden Software) | 2.5 |
| Switch (NCH Software) | 1.9 |
| Synfig Studio (Synfig Studio Development Team) | 3.7 |