| Mac Media Player (Macgo) | 3.0 |
| MacGourmet Deluxe (Mariner Software) | 2.9 |
| MacMAME | 2.3 |
| MacVim | 3.3 |
| MagicISO | 3.5 |
| Mail (Apple) | 3.2 |
| Make (GNU) | 2.5 |
| MakerBot Desktop (MakerBot Industries) | 2.0 |
| MAME | 3.6 |
| MAME OS X (Dave Dribin) | 2.9 |
| Mathematica (Wolfram Research) | 2.7 |
| MATLAB (The MathWorks) | 3.4 |
| Maxwell Render (Next Limit) | 3.1 |
| Maya (Autodesk) | 2.7 |
| Media Center (JRiver) | 3.4 |
| Media Composer (Avid) | 3.3 |
| Media Converter (antvplayer) | 3.3 |
| Media Player Classic | 4.0 |
| Media Suite (CyberLink) | 2.5 |
| MEGA (MEGA Team) | 3.3 |
| Melody Assistant (Myriad) | 3.1 |
| Merkaartor | 3.2 |
| MeshLab | 3.2 |
| messiahStudio (pmG) | 2.4 |
| MetaTrader (MetaQuotes Software) | 2.5 |
| MikMod | 1.5 |
| MiKTeX | 2.5 |
| MilkShape 3D (chUmbaLum sOft) | 2.4 |
| MindManager (Corel) | 4.0 |
| MINDSTORMS EV3 (LEGO) | 3.3 |
| MindView for Mac (MatchWare) | 2.3 |
| MindView for Windows (MatchWare) | 3.3 |
| Minecraft (Mojang) | 4.1 |
| MKDS Course Modifier | 3.7 |
| Mobile Atlas Creator | 3.0 |
| MODPlug Player (Olivier Lapicque) | 3.9 |
| Movie Edit Pro (MAGIX) | 2.3 |
| MPEG Streamclip (Squared 5) | 3.1 |
| MPlayer | 3.6 |
| MSC Nastran (MSC Software) | 3.1 |
| Multisim (National Instruments) | 3.1 |
| MuseScore | 3.5 |
| Music (Apple) | 4.4 |
| Music Maker (MAGIX) | 2.1 |
| MX Player for Android (J2 Interactive) | 3.5 |
| MySQL (Oracle) | 3.5 |