MPEG-4 Video File
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What is an M4E file?
An M4E file is a video file that can be played by various video players, including QuickTime Player and Roxio Popcorn. It contains a movie or video clip compressed with MPEG-4 compression. M4E files are more commonly seen as an .MP4 file.
You will most likely never come across the M4E file since it is an obscure file extension. However, you may receive the file through an email from a colleague or download from the Internet. The best option to play the file is to use QuickTime Player.