ClickOnce Deployment Manifest File
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What is an APPLICATION file?
File created for ClickOnce, a Microsoft framework used to deploy Windows applications over the Web; stores program deployment properties in an XML format, including name, version, description, deployment options, and dependencies; may also contain a digital signature.
APPLICATION files were designed to provide easy "one click" deployments of user-level Windows applications. They have a corresponding .APPREF-MS file that activates ClickOne for a program, which subsequently executes within the .NET framework in Windows.